Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation
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Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation
The Abl and Arg tyrosine kinases play fundamental roles in the development and function of the central nervous system. Arg is most abundant in adult mouse brain, especially in synapse-rich regions. arg(-/-) mice develop normally but exhibit multiple behavioral abnormalities, suggesting that arg(-/-) brains suffer from defects in neuronal function. Embryos deficient in both Abl and Arg suffer fr...
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ژورنال
عنوان ژورنال: Neuron
سال: 1998
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)80646-7